Turner Syndrome Research Today is a free monthly online journal that collates and summarizes the latest research about Turner Syndrome, including details on symptoms, causes, chromosomes, prognosis.

Hepatic Enzyme Abnormalities in Turner Syndrome: A Case Report.

Pervanidou P, Xekouki P, Dacou-Voutetakis C

First Department of Pediatrics, Division of Endocrinology, Metabolism and Diabetes, University of Athens, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece.

Background: Liver dysfunction has been described in subjects with Turner syndrome. The mechanism involved is not known. Methods: Using appropriate methodology, we evaluated the hepatic enzymes serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase and gamma-glutamyl transpeptidase (gamma-GT) in a girl with 45 XO/46 Xr mosaic karyotype. She was monitored from age 9 to 20 years while she underwent various therapeutic regimens. Results: Serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase and particularly gamma-GT concentrations ranged from normal to elevated values during human growth hormone therapy, estrogen replacement therapy (conjugated estrogens were replaced after 1 year with transdermal estrogens and medroxyprogesterone), and periods without therapy. The type of the therapeutic regimen did not seem to influence the hepatic enzyme values. A correlation was found between gamma-GT values and body mass index (BMI). Conclusions: In our patient the waxing and waning of the liver enzymes was not influenced by the therapeutic regimen, but gamma-GT seemed to correlate with BMI. Copyright (c) 2007 S. Karger AG, Basel.

Published 19 February 2007 in Horm Res, 67: 106-108.
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